The reaction is named after the Italian chemist Mario Betti (1857-1942). Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. Division of Cardiovascular Medicine, Radcliffe Department of Medicine, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford, UK. Facile green synthesis and potent antimicrobial efficacy of β-aminoheteronapthol via tailored Betti’s protocol and their bis-aryl hydrazone click products. Please note: If you switch to a different device, you may be asked to login again with only your ACS ID. and you may need to create a new Wiley Online Library account. Instructions for using Copyright Clearance Center page for details. O Catalyzed Multicomponent Synthesis of 1-(Benzothiazolylamino) Methyl-2-Naphthols Under Solvent-Free Conditions. of the whole article in a thesis or dissertation. Henry Wellcome Building for Molecular Physiology, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, Oxford, OX3 7LD, UK, e Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. E-mail: K M KHANDARKAR, M D SHANTI, M AHMED, J S MESHRAM. Synthesis and Characterization of Novel Betti Type Cyanate Esters. DOI: 10.1016/j.tetlet.2011.07.075.. Ester Pyrolysis. Find more information on the Altmetric Attention Score and how the score is calculated. This may take some time to load. Betti worked at many universities in Italy, including Florence, Cagliari, Siena, Genoa and Bologna, where he was the successor of Giacomo Ciamician. In all cases the Ref. A large library of compounds is obtained by the Betti reaction of cyclic imines with activated phenols and naphthols. 20 publications. This reaction involves the components of an ammonia, a 2‐naphthol, and at least one benzaldehyde to give either a phenyl β‐naphtholaminomethane or a m‐naphthoxazine derivative. Find more information about Crossref citation counts. Working off-campus? If you are the author of this article you do not need to formally request permission Get article recommendations from ACS based on references in your Mendeley library. A competent pot and atom-efficient synthesis of Betti bases over nanocrystalline MgO involving a modified Mannich type reaction. Journal of Molecular Catalysis A: Chemical. If you are not the author of this article and you wish to reproduce material from For reproduction of material from all other RSC journals and books: For reproduction of material from all other RSC journals. Please enable JavaScript Corresponding authors, a If you are the author of this article you still need to obtain permission to reproduce You’ve supercharged your research process with ACS and Mendeley! Reproduced material should be attributed as follows: If the material has been adapted instead of reproduced from the original RSC publication All the generated Betti bases can decompose to give β‐naphthol and benzaldehyde, especially in alkaline solution. Mohammad Ali Zolfigol, Saeed Baghery, Ahmad Reza Moosavi-Zare, Seyed Mohammad Vahdat. XX is the XXth reference in the list of references. Comprehensive Organic Name Reactions and Reagents. Learn about our remote access options. NaHSO article provided that the correct acknowledgement is given with the reproduced material. Information about reproducing material from RSC articles with different licences is available on our Permission Requests page. Find more information about Crossref citation counts. Abstract A large library of aminocycloalkylphenols and ‐naphthols is obtained by the Betti reaction between activated phenols and naphthols and five‐ and six‐membered cyclic imines. One-Pot, Three-Component Uncatalyzed Quantitative Synthesis of New Aminonaphthols (Betti Bases) in Water. Synthesis of Novel 8-Hydroxyquinoline Derivatives through Mannich Reaction and their Biological Evaluation as Potential Immunomodulatory Agents. Browse other articles of this reference work: The full text of this article hosted at iucr.org is unavailable due to technical difficulties. 2 Convenient and Efficient Method for the Synthesis of N-Heteroaryl Aminonaphthols under Solvent-Free Conditions. C. C. Thinnes, A. Tumber, C. Yapp, G. Scozzafava, T. Yeh, M. C. Chan, T. A. Tran, K. Hsu, H. Tarhonskaya, L. J. Walport, S. E. Wilkins, E. D. Martinez, S. Müller, C. W. Pugh, P. J. Ratcliffe, P. E. Brennan, A. Kawamura and C. J. Schofield, Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Mansfield Road, Oxford, UK, Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Headington, UK, Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, UK, Henry Wellcome Building for Molecular Physiology, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, Oxford, OX3 7LD, UK, Hamon Center for Therapeutic Oncology Research, UT Southwestern Medical Center at Dallas, Dallas, USA, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford, UK, Instructions for using Copyright Clearance Center page. Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Headington, UK, c These metrics are regularly updated to reflect usage leading up to the last few days. Kojic acid has been reported to be the most reactive compound. Your Mendeley pairing has expired. Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Kojic acid has been reported to be the most reactive compound. Synthesis and characterization of some novel copper(II) complexes with an optically active Betti base. https://doi.org/10.2174/1573406415666190626121650, https://doi.org/10.1016/j.micromeso.2018.12.018, https://doi.org/10.1007/s13738-016-0981-0, https://doi.org/10.1016/j.bmc.2015.11.043, https://doi.org/10.1016/j.molcata.2015.09.001, https://doi.org/10.1007/s12039-013-0509-4, https://doi.org/10.1016/j.tet.2012.11.055, https://doi.org/10.1080/10426507.2012.664221, https://doi.org/10.1016/j.poly.2011.12.034, https://doi.org/10.1016/j.tetlet.2011.07.075, https://doi.org/10.1002/9780470638859.conrr082, https://doi.org/10.1080/00397910802279860, https://doi.org/10.1007/s00289-008-0947-1, https://doi.org/10.1016/S0957-4166(98)00379-6, https://doi.org/10.1007/978-3-642-86313-4_4, https://doi.org/10.1016/S0003-2670(00)88194-5. Syntheses, transformations and applications of aminonaphthol derivatives prepared via modified Mannich reactions. It has also observed, when a stoichiometric amount of naphthol, amine, and 2 equivalents of aldehyde are used, the resulting Betti base can further react with additional aromatic aldehyde. The 3-component Betti reaction enables efficient one-step C-7 functionalisation of modified 8-hydroxyquinolines (8HQs) to produce cell-active inhibitors of KDM4 histone demethylases and other 2OG oxygenases; the work exemplifies how a template-based metallo-enzyme inhibitor approach can be used to give biologically active compounds. Phosphorus, Sulfur, and Silicon and the Related Elements. Authors contributing to RSC publications (journal articles, books or book chapters) This article is cited by In this reaction, the course of condensation and the type of products formed have been found to depend on several factors. There is interest in developing potent, selective, and cell-permeable inhibitors of human ferrous iron and 2-oxoglutarate (2OG) oxygenases for use in functional and target validation studies. A competent pot and atom-efficient synthesis of Betti bases over nanocrystalline MgO involving a modified Mannich type reaction. Abolfazl Olyaei, Saeed Raoufmoghaddam, Mahdieh Sadeghpour, Behruz Ebadzadeh. Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, UK, d to reproduce figures, diagrams etc. A green protocol for one-pot three-component synthesis of 1-(benzothiazolylamino) methyl-2-naphthol catalyzed by oxalic acid. Fetching data from CrossRef. It has also observed, when a stoichiometric amount of naphthol, amine, and 2 equivalents of aldehyde are used, the resulting Betti base can further react with additional aromatic aldehyde. 4 You do not have JavaScript enabled. Reda M. Abdelhameed, Rabab A. Ismail, Mohamed El-Naggar, Eman S. Zarie, Ramzy Abdelaziz, Mardia T. El Sayed. Figure 3, Betti reaction of 8-hydroxyquinolines (X = N): general synthesis scheme for preparing the probe ML311 and all analogs - Probe Reports from the NIH Molecular Libraries Program. ing.1 The Betti reaction2 originated as a condensation of Schiff bases with 2-naphthol,3,4 but it was later extended to other nucleophilic aromatic substrates, e.g., 8-hydroxyquinoline.5 While a chiral center is formed in this reaction, the products are typically racemic mixtures, as … Mykhaylo S. Frasinyuk, Galyna P. Mrug, Svitlana P. Bondarenko, Vitaliy M. Sviripa, Wen Zhang, Xianfeng Cai, Michael V. Fiandalo, James L. Mohler, Chunming Liu, David S. Watt. .H to access the full features of the site or access our. A large library of aminocycloalkylphenols and ‐naphthols is obtained by the Betti reaction between activated phenols and naphthols and five‐ and six‐membered cyclic imines. the whole article in a third party publication with the exception of reproduction Synthesis and characterization of new 1-(α-aminoalkyl)-2-naphthols using pyrazine-1,4-diium trinitromethanide {[1,4-DHPyrazine][C(NO2)3]2} as a novel nano-structured molten salt and catalyst in compared with Ag–TiO2 nano composite.

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